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The Bioinformatics Behind Eli Lilly’s Oral GLP-1 Breakthrough: A Computational Journey from Molecule to Medicine
Introduction Eli Lilly's recent announcement of successful Phase 3 trial results for orforglipron marks a significant milestone in metabolic disease treatment. As the first small molecule oral GLP-1 receptor agonist to complete a Phase 3 trial, orforglipron has...
How to Upload Local Scripts to a Specific Folder in a GitHub Repository
How to Upload Local Scripts to a Specific Folder in a GitHub Repository Use Case: You have a set of files (e.g., .py, .ipynb, etc.) on your local machine and want them to appear inside a specific...
Exploring Hypoxia-Induced Gene Expression and Pathway Alterations in Prostate Cancer Cells
Abstract Hypoxia, a condition of reduced oxygen, drives significant changes in prostate cancer progression. This study analyzes the impact of hypoxia on gene expression in two prostate cancer cell lines, LNCaP (androgen-sensitive) and PC3 (androgen-independent), using...

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RNA-seq Analysis Pipeline

RNA-seq Analysis Pipeline

A Step-by-Step Guide to RNA-seq Data Processing: From Data Download to Raw Counts In this article, I will walk you through the process of analyzing RNA-seq data, starting from downloading the raw data to obtaining gene expression counts. This is an essential workflow...

Different types of Bioinformatics data

Bioinformatics data encompasses various types, each crucial for advancing our understanding of biological systems and enhancing medical research. Bioactivity data reveals how compounds interact with biological systems, essential for drug discovery and safety...

Evolution of DNA Sequence Alignment: Key Milestones

From the foundational Needleman-Wunsch Algorithm in 1970 to AI-powered techniques in 2024, the field of DNA sequence alignment has seen transformative advancements. These innovations have revolutionized genomics, making sequence analysis faster, more accurate, and...