Abstract Hypoxia, a condition of reduced oxygen, drives significant changes in prostate cancer progression. This study analyzes the impact of hypoxia on gene expression in two prostate cancer cell lines, LNCaP (androgen-sensitive) and PC3 (androgen-independent), using...
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Rshiny Single Cell RNA-seq Analysis Dashboard
Introduction As a student in bioinformatics, I am constantly dealing with data from single-cell RNA sequencing (scRNAseq). Analyzing these large datasets can be challenging, especially when it comes to visualizing and exploring clusters within the data. So, for one of...
Exploring Gene Expression Changes in Prostate Cancer Cells Under Hypoxia
In this project, I explore differential gene expression and pathway enrichment in two prostate cancer cell lines—LNCaP and PC3—under different oxygen conditions: hypoxia (low oxygen) and normoxia (normal oxygen). Hypoxia is a common feature of tumor environments and...
Understanding Genome Assembly Using De Bruijn Graphs: From Concepts to Code
Genome assembly is a key concept in bioinformatics, and it involves reconstructing a long DNA sequence from short, overlapping fragments known as reads. The purpose of this article is to explain how we can use De Bruijn graphs and Eulerian paths to solve genome...
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My Role as a Graduate Ambassador at the Luddy School of Informatics
As a Graduate Ambassador at the Luddy School of Informatics, Computing, and Engineering at Indiana University, I play a pivotal role in bridging the gap between the university and prospective students. This position allows me to engage in a variety of activities aimed...
Different types of Bioinformatics data
Bioinformatics data encompasses various types, each crucial for advancing our understanding of biological systems and enhancing medical research. Bioactivity data reveals how compounds interact with biological systems, essential for drug discovery and safety...
Evolution of DNA Sequence Alignment: Key Milestones
From the foundational Needleman-Wunsch Algorithm in 1970 to AI-powered techniques in 2024, the field of DNA sequence alignment has seen transformative advancements. These innovations have revolutionized genomics, making sequence analysis faster, more accurate, and...
Trailmaker: Single Cell Data Analysis | Parse Biosciences
Exciting news from the forefront of single-cell RNA sequencing! Just attended an in-depth session on Trail Maker, an innovative platform transforming how we analyze and understand cellular data. Key Highlights: Complete Single-cell RNA Sequencing Solution: Trail Maker...
Bioinformatics essential file formats and functions
In the rapidly evolving field of bioinformatics, understanding the different file formats is crucial for data analysis and research. Here's a quick guide to some of the most commonly used bioinformatics files
A dynamic dashboard visualizing Gene Expression Data
Exciting News for Data Enthusiasts and Bioinformatics Professionals! I am thrilled to share my latest project - a dynamic dashboard visualizing Gene Expression Data, created using R Shiny. This tool is designed to help researchers and data scientists gain insights...
A Practical Guide to Interpreting Proteomics Data Visualization
Data visualization plays a crucial role in analysis by bridging the gap between data and results. Mass spectrometry facilitates an in-depth examination of complex proteomes. Given the widespread availability of mass spectrometry, we are now faced with a vast amount of...
Luddy Journal Club
Unlocking the World of Knowledge with Luddy Journal Club! Hey, knowledge enthusiasts! I'm Swaraj, your go-to person as the Journal Committee Chair of the Biomedical Informatics Club (aka the proud President of the Luddy Journal Club). Today, let's chat about the...
Advance Python
For individuals with a foundational grasp of Python looking to push the boundaries of coding, this video offers valuable insights. It provides hands-on experience to delve deeper and encourages thinking in a slightly different way. I recommend this video; feel free to fast forward and focus on learning the concepts. Happy coding!